Diagnosis
Barış Gülhan and others
Rapid diagnosis of pathogens grown in blood cultures reduces mortality and morbidity as appropriate treatment is started early. It notably reduces hospital costs because of less need for intensive care and earlier patient discharge. Although rapid identification and antibiogram of pathogens can be made with automated blood [...] Read More
Muhammet Çağrı Yıldız and others
Real-time reverse transcriptase polymerase chain reaction (RT-PCR) is widely used to diagnose SARS-CoV-2. However, PCR tests need expensive equipment and qualified personnel, which makes them only used in high throughput and advanced laboratory settings. Improvements in SARS-CoV-2 diagnosis with easy, rapid, and cost-effective approaches […] Read More
Kadir Görkem Güçlü and others
Hepatitis B virus (HBV) infection remains a significant public health issue globally. According to the latest data released by the World Health Organization (WHO) in July 2023, the number of individuals living with chronic hepatitis B (CHB) infection as of 2019 was reported as 296 million, with 820 million deaths attributed to cirrhosis and hepatocellular carcinoma [...] Read More
Hasan Selçuk Özger and others
Procalcitonin (PCT) is a biomarker frequently used in the diagnosis and prognosis of infection. The lack of optimum cut-off values and the high serum PCT levels in some non-infectious conditions restrict its clinical use. Therefore, PCT use is not recommended regardless of clinical parameters. This limitation in clinical use has led to PCT kinetic evaluations rather than predictions [...] Read More
Mervenur Demir and Gülşen Hazırolan
Sepsis is a life-threatening infection with a mortality rate above 25%. Rapid identification of the microorganisms that cause bloodstream infections is important for choosing targeted and timely antimicrobial treatment. The implementation of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (...) Read More
Muhammet Çağrı Yıldız and others
Polymerase chain reaction (PCR) test is used in high-capacity laboratories in the diagnosis of COVID-19. On the other hand, rapid SARS-CoV-2 antigen tests require less technical expertise and laboratory capacity. Antigen tests, which are faster and cost-effective, are increasingly used in COVID-19 screening and diagnosis. This study aimed to compare the i-test (...) Read More
Uğur Önal and others
Lyme disease, also known as Lyme borreliosis, is the most common vector-borne disease in Europe and North America, caused by the spirochete Borrelia species, which can be transmitted through the bite of an infected black-legged tick. The Centers for Disease Control and Prevention (CDC) data on Lyme disease in the United States showed (...) Read More
Grace Fisler and others
Elevated procalcitonin levels are associated with increased bacterial infection rates in children and adults. Identification of bacterial infection in previous studies has used procalcitonin thresholds of 0.5 ng/mL-1.0 ng/mL. Procalcitonin level elevations have been reported in COVID-19 patients (...) Read More
Deniz Gür-Altunay and Pınar Yürük-Atasoy
Hepatitis B virus (HBV) infection is an important public health problem worldwide. It is the most important cause of acute and chronic liver disease and hepatocellular cancer. Hepatitis B infection is diagnosed by the detection of HBsAg in the serum or plasma. Chronic hepatitis B (CHB) infection is defined as the persistence of (...) Read More
Yağmur Eylül Doğantürk and others
Human adenovirus (HAdV) is a non-enveloped, double-stranded DNA virus that causes self-limiting respiratory system infections, gastrointestinal tract infections, conjunctivitis, and meningitis. These infections are generally observed throughout the year with no seasonal distribution. Despite being self-limiting, HAdV infections (...) Read More
Reza Kamali Kakhki* and others
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory disease agent belonging to the Betacoronavirus genera. The genome of the virus translates into four major structural proteins, including spike (S), nucleocapsid (N), membrane (M), and envelop (E) proteins. During the pandemic, huge numbers of mutations (...) Read More
Murat Erdem and others
The standard method to detect SARS-CoV-2 has been real-time polymerase chain reaction (RT-PCR). Regardless of its high sensitivity and specificity, this method has some drawbacks as it requires complex and expensive equipment, extensive user training, (...) Read More
Çiğdem Erol and others
Candida species are major sources of morbidity and mortality in healthcare settings. These infections are predominantly connected with medical procedures. The five most prevalent pathogens- Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis, and Candida krusei – are responsible for (...) Read More
Çiğdem Akalan Kuyumcu and others
Brucellosis is a zoonotic infectious disease caused by Gram-negative bacteria of the genus Brucella, which is transmitted from animals to humans by direct and indirect pathways. Brucellosis can be confused with various infectious and non-infectious diseases because of its nonspecific clinical signs and symptoms such as fever, sweating, Read More
Özgür Kurt and others
Dientamoeba fragilis is an intestinal protozoon classified among the flagellates inhabiting in the caecum and colonic lumen of humans. It has long been regarded as a commensal microorganism until when clinical reports indicate its association with gastrointestinal and dermatological case. Laboratory diagnosis of D. fragilis infections has long been limited to (...) Read More