Treatment
Hanife Nur Karakoç-Parlayan and others
The demographic shift with an aging population worldwide has highlighted the unique healthcare challenges the elderly face. According to the Turkish Statistical Institute data, the population aged 65 and over reached 8,722,806 in 2023, accounting for 10.2% of the total population. Population projections indicate that the proportion of the elderly population is expected to reach 12.9% in 2030 [...] Read More
Aybegüm Özşahin and others
With the prolongation of life expectancy and the developments in orthopedic surgery, noteworthy progress has been made in prosthetic joint surgery in recent years. Joint replacement provides pain relief, improves quality of life, and gives independence to individuals. Along with the advances in prosthetic surgery, prosthetic joint infection (PJI) is still the most feared complication of the procedure. Read More
Ebru Yücebağ-Duranay and others
Human pegiviruses (HPgV-1 and HPgV-2) are enveloped, single-stranded positive-sense RNA viruses belonging to the Pegivirus genus in the Flaviviridae family. HPgV has a genome of 8.9-11.3 kb, and the virion size is estimated at around 50-100 nm. Seven genotypes of HPgV-1 differ geographically. Two subtypes of genotype (GT) 2, which is common in Europe [...] Read More
Yusuf Emre Özdemir and others
Peritonitis presents an inflammation of the peritoneal cavity that can develop because of infectious (bacteria, viruses, parasites, etc.) and non-infectious (chemical agents, foreign substances, etc.) causes. Infectious peritonitis is divided into three classes based on [...] Read More
İlker Devrim and others
The most common and serious complication of central venous catheter usage is central line–associated bloodstream infections (CLABSIs) in children and adults. Between 2011 and 2014, CLABSIs were the most frequently reported healthcare-associated illness among hospitals in the USA. Bloodstream infections associated with central lines are […] Read More
Oruç Numan Gökçe and others
Cystic echinococcosis (CE), caused mainly by Echinococcus granulosus, is a parasitic disease common in Mediterranean countries such as Türkiye. Although it can occur anywhere in the body, it predominantly affects the liver. The disease is often asymptomatic; thus, cysts are often detected incidentally during imaging studies performed for other purposes. Read More
Süreyya Damar-Örenler and others
Human immunodeficiency virus (HIV) remains a significant global health challenge with societal impacts. Despite a decline in the annual number of new cases worldwide, the incidence of HIV is on the rise in the Eastern Europe/Central Asia region, including Türkiye. With the introduction of new antiretroviral treatments (ARTs), HIV has transitioned from a […] Read More
Kauke Bakari Zimbwe and others
Antimicrobial resistance (AMR) is declared one of humanity’s top ten global public health threats. AMR is associated with increased hospitalizations, extended hospital stays, readmissions, and a higher mortality risk. In 2019, 4.95 million deaths, including 1.27 million directly attributable, were associated with bacterial AMR. Sub-Saharan Africa has the highest all-age death rate [...] Read More
Yunus Gürbüz and others
In 75-85% of cases of acute hepatitis C infection, the disease becomes chronic and carries a risk of developing liver failure and hepatocellular cancer. In its global hepatitis report published in 2017, the World Health Organization (WHO) reported that 71.1 (95% uncertainty interval [UI]: 62.1-79.0 million) million people were chronically infected with the hepatitis C virus [...] Read More
Pınar Korkmaz and Neşe Demirtürk
Chronic hepatitis B (CHB) remains a major threat to global public health, affecting 296 million people worldwide. CHB increases the risk of cirrhosis, liver failure and hepatocellular carcinoma, causing liver-related morbidity and mortality. All these risks can be prevented with antiviral treatment. Although there is no curative treatment for CHB today the virus can be effectively controlled with existing (...) Read More
Zeynep Tekin-Taş and others
Hip and knee arthroplasties stand out as the most prevalent surgical interventions employed to address joint deformities, predominantly stemming from osteoarthritis associated with an aging population. In Turkey, a total of 34,240 hip arthroplasties and 81,109 knee arthroplasties were conducted in 2022. Meanwhile, in the United States of America (...) Read More
Elif M. Sarıcaoğlu and Fügen Yörük
Staphylococcus aureus, particularly methicillin-resistant Staphylococcus aureus (MRSA), is a major cause of serious hospital and community-acquired infections and is associated with increased health care costs, prolonged antibiotic treatment and hospitalization, morbidity, and mortality. While glycopeptides (...) Read More
Mervenur Demir and others
The global increase in the rate of multi-drug resistant (MDR) bacterial infections in recent years is an important public health problem that limits the therapeutic options. The issue becomes particularly critical in cases of bloodstream infections (BSI) in which delay is associated with high mortality rates. Bacteria grown in blood cultures (BC) must be subcultured on the solid media (...) Read More
Pınar Korkmaz and others
Antimicrobial resistance can lead to morbidity and mortality in serious infections. Therefore, antimicrobial resistance has been accepted as a global public health problem in the 21st century. Unnecessary and excessive use of drugs is a serious problem in our country as well as in the rest of the world. Unnecessarily used drugs play an important role (...) Read More
Ramazan Çakmak and Murat Bektaş
Coronavirus disease 2019 (COVID-19) is a potentially life-threatening disease caused by SARS-CoV-2. Clinical findings of COVID-19 are ranged from asymptomatic to severe pneumoniae, acute respiratory distress syndrome, multiorgan failure and death. A severe COVID-19 course is associated with a higher inflammatory state (cytokine storm) due to the excessive release (...) Read More
Pınar Korkmaz and others
Hepatitis B virus (HBV) infection is the leading cause of chronic liver disease worldwide. HBV-infected patients are at risk of developing liver cirrhosis and hepatocellular carcinoma (HCC) for life. Today, pegylated interferon (Peg-IFN) and nucleos(t)ide analogues (NAs) are used in the treatment of patients with chronic hepatitis B (CHB). Both treatment options have limitations. Read More
Serap Şimşek-Yavuz
After the World Health Organization (WHO) declared an end to COVID-19 as a global public health emergency on May 5, 2023, we have entered a new era in the pandemic, and most countries have already returned to normal life. This declaration was resulted from the 12-month downward trend of the pandemic, increased immunity due to the highly effective vaccines, decreased death rates, and decreased pressure on once overwhelmed (...) Read More
Özge Kaya and others
Psoriasis, a chronic inflammatory disease, has a multifactorial etiology, including genetic, environmental, and behavioral factors. Since psoriasis is an immune system-mediated disease, immunosuppressive agents and biological treatments are frequently used in its treatment; however, these agents are known to increase the risk of infection. This situation (...) Read More
Betül Çopur and others
COVID-19 is a fatal disease affecting all systems, especially the respiratory system. It manifests with different clinical characteristics, from asymptomatic infection to severe infection. Since its initial description, the disease has caused devastating effects and many deaths. Predictors of mortality (...) Read More
Oruç Numan Gökçe and others
Many parts of the world are affected by Echinococcus granulosus. This helminthic zoonosis leads to important public health and economic burdens in endemic regions. E. granulosus can even lead to death if complications occur. Dogs are the definitive hosts of E. granulosus, where the larval state, (...) Read More