The Official Journal of the Turkish Society Of Clinical Microbiology and Infectious Diseases (KLİMİK)

Review Article

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Review Article / VOLUME 1, ISSUE 3, DECEMBER 2019

Rare Yeasts: Emerging Threat in Immunocompromised Patients

Mahir Kapmaz and others

Infections of the yeasts other than Candida spp. are rare, but an emerging clinical entity. Clinicians should be alert for early diagnosis. Early distinction of non-Candida yeasts is important because of varying antifungal susceptibilities, higher mortality of 50-80% particularly among immunocompromised patients. These yeasts include Basidiomycetes […] Read More

Review Article / VOLUME 1, ISSUE 3, DECEMBER 2019

Splenic Actinomycosis in a Patient with Chronic Granulomatous Disease: A Case Report and Review of the Literature

Çağlayan Merve Ayaz and others

Actinomycosis, a chronic granulomatous condition, is caused by Actinomyces spp., a gram-positive anaerobic bacterium. Actinomyces spp. usually inhabit oral, gastrointestinal and female genital tract. The disease commonly manifests as slowly progressive cervicofacial (50% of cases), thoracic and pulmonary (15-20% ) or abdominopelvic (about 20% ) infection. Immunosuppression […] Read More

Review Article / VOLUME 1, ISSUE 3, DECEMBER 2019

Infections Caused by Extended-Spectrum β-lactamase-Producing Enterobacteriaceae: Clinical and Molecular Epidemiology and Treatment Strategies

Abdullah Tarık Aslan and Murat Akova

Origins, characteristics and classification of extended-spectrum beta-lactamases (ESBLs) Currently, beta-lactamase family includes more than 2800 unique proteins. Although varied types of beta-lactamases have been specified to date, they have common topographic structures consisting of alpha-helices and beta-plated sheets. They most probably originated from environmental sources and produced against naturally occurring […] Read More

Review Article / VOLUME 2, ISSUE 1, APRIL 2020

Mental Health Consequences of COVID-19 Disaster

Gamze Özçürümez Bilgili

Disasters are large-scale events that are often unexpected and cause death, trauma, and destruction of property. Although there is no consistent definition of disasters in the literature, researchers generally agree that disasters share three key characteristics of large-scale traumatic events. First, disasters threaten to harm or death to a large group of people, Read More

Review Article / VOLUME 2, ISSUE 1, APRIL 2020

Policy Analysis of Suppression and Mitigation Strategies in the Management of an Outbreak Through the Example of COVID-19 Pandemic

İlker Kayı and Sibel Sakarya

In the statement he gave to the television program Nieuwsuuer on March 16, Sunday evening, the Head of Dutch National Institute for Public Health and the Environment (RIVM) Jaap van Dissel maintained that ‘an approach of total lockdown would lead the COVID-19 to bounce back’ and thereby they would employ the ‘maximum control’ strategy. Read More

Review Article / VOLUME 2, ISSUE 2, AUGUST 2020

Candida Infections: Clinical Features, Diagnosis and Treatment

S.P. Bouopda Tamo

Each year, fungal infections affect more than one billion people worldwide, with more than 1.6 million deaths. Candidiasis accounts for 75 to 88% of these infections, and despite therapeutic advances, their incidence continues to increase with increasing mortality. The clinical spectrum of candidiasis extends from superficial diseases such as cutaneous, nail, digestive, and genital candidiasis, to systemic diseases such as candidemia. Read More

Review Article / VOLUME 4, ISSUE 4, DECEMBER 2022

HIV Pre-Exposure Prophylaxis in Central and Eastern Europe-Gains and Challenges in An Ever-Changing World

Deniz Gökengin

It has been more than a decade since the first evidence of oral pre-exposure prophylaxis (PrEP) in the “Iniciativa Profilaxis Pre-Exposición” (iPreEx) study, which reported 44% efficacy. Following these results, the US Food and Drug Administration (FDA) approved PrEP in 2012 as a method of prevention from HIV for individuals at high risk, and two years later, the Centers for Disease Control and Prevention (CDC) published the PrEP guidelines. Then, many other (...) Read More

Review Article / VOLUME 5, ISSUE 2, JUNE 2023

Opportunistic Infections Among Human Immunodeficiency Virus (HIV) Infected Patients in Turkey: A Systematic Review

Uğur Önal and Halis Akalın

Patients with human immunodeficiency virus (HIV) infection or AIDS are more likely to have diseases that would not usually cause illness in a person with a healthy immune system, called opportunistic infections. Although significant efforts to improve progression along the HIV care continuum, (...) Read More

Review Article / VOLUME 5, ISSUE 3, SEPTEMBER 2023

The Effect of Prophylactic Carbapenem Use on Outcomes in Acute Pancreatitis: A Systematic Review and Meta-Analysis

Merve Büyükkörük and others

The incidence of acute pancreatitis ranges from 2.2-136/100,000 people and increases by 3.7% per year. Necrosis occurs in nearly 15% of acute pancreatitis. The sterile necrosis of pancreatic or peripancreatic tissue gets infected by translocation of gastrointestinal flora or peripheral spread from the skin, respiratory, or urinary tract. Mortality rates increase with infection in necrotic tissue and rise from 19.8% to 35.2% in acute pancreatitis . Read More

Review Article / VOLUME 5, ISSUE 3, SEPTEMBER 2023

COVID-19: An Update on Epidemiology, Prevention and Treatment, September-2023

Serap Şimşek-Yavuz

After the World Health Organization (WHO) declared an end to COVID-19 as a global public health emergency on May 5, 2023, we have entered a new era in the pandemic, and most countries have already returned to normal life. This declaration was resulted from the 12-month downward trend of the pandemic, increased immunity due to the highly effective vaccines, decreased death rates, and decreased pressure on once overwhelmed (...) Read More

Review Article / VOLUME 5, ISSUE 4, DECEMBER 2023

Is There a Role for Dark Field Microscopy in the Diagnosis of Lyme Disease?
A Narrative Review

Uğur Önal and others

Lyme disease, also known as Lyme borreliosis, is the most common vector-borne disease in Europe and North America, caused by the spirochete Borrelia species, which can be transmitted through the bite of an infected black-legged tick. The Centers for Disease Control and Prevention (CDC) data on Lyme disease in the United States showed (...) Read More

Review Article / VOLUME 5, ISSUE 4, DECEMBER 2023

New Treatment Options in Chronic Hepatitis B: How Close Are We to Cure?

Pınar Korkmaz and others

Hepatitis B virus (HBV) infection is the leading cause of chronic liver disease worldwide. HBV-infected patients are at risk of developing liver cirrhosis and hepatocellular carcinoma (HCC) for life. Today, pegylated interferon (Peg-IFN) and nucleos(t)ide analogues (NAs) are used in the treatment of patients with chronic hepatitis B (CHB). Both treatment options have limitations. Read More

Review Article / VOLUME 6, ISSUE 2, JUNE 2024

Discontinuation of Nucleos(t)ide Analogues in HBeAg Negative Chronic Hepatitis B Patients: Risks and Benefits

Pınar Korkmaz and Neşe Demirtürk

Chronic hepatitis B (CHB) remains a major threat to global public health, affecting 296 million people worldwide. CHB increases the risk of cirrhosis, liver failure and hepatocellular carcinoma, causing liver-related morbidity and mortality. All these risks can be prevented with antiviral treatment. Although there is no curative treatment for CHB today the virus can be effectively controlled with existing (...) Read More